7 Best NAD+ Supplements in 2024

Nicotinamide adenine dinucleotide (NAD+) supplements are creating a buzz in the health and wellness community for their profound impact on cellular health and longevity. These supplements are not just another health trend you may have picked up from a podcast; they are based on a solid scientific understanding of cellular metabolism.

This article explores the 7 best NAD+ supplements, diving deep into what NAD+ is, the substantial benefits it offers, and the potential risks associated with its supplementation. We’ll explore everything from the molecular mechanism of NAD+ in the body to the best practices for supplementing with NAD+, offering a comprehensive guide for anyone looking to enhance their health at the cellular level.

1. Thorne Niacinamide (NAD)

The best NAD supplement is Thorne Niacinamide. Thorne Research offers a premium niacinamide supplement to support cellular health as a non-flushing form of vitamin B3. Niacinamide serves as an NAD+ precursor and methyl acceptor involved in over 400 enzymatic reactions.

Thorne Niacinamide NAD
Thorne Niacinamide (NAD)

As an antioxidant, niacinamide helps inhibit free radicals and regenerate pancreatic cells. It also promotes skin, joint, and sleep health. Thorne’s high-purity formula contains no major allergens or additives.

Niacinamide’s ability to stimulate neurotransmitter receptors creates a calming effect on the mind. It also protects joint cartilage and benefits various skin conditions when applied topically.

Thorne Niacinamide aims to provide optimal vitamin B3 levels without flushing side effects. Those seeking an additive-free niacin supplement for antioxidant benefits, cellular support, cognition, and skin/joint health may find value in this purified formula.

2. Orgabay Liposomal NAD+ Supplement

Orgabay offers a liposomal NAD+ supplement to elevate levels of this vital cellular coenzyme for anti-aging benefits. Each softgel provides 500mg NAD+ plus 250mg trimethylglycine, enveloped in phospholipids for enhanced absorption compared to regular NAD+ capsules.

Orgabay Liposomal NAD Supplement
Orgabay Liposomal NAD+ Supplement

As we age, NAD+ depletion leads to cellular dysfunction and declines in energy, cognition, and health. Orgabay’s high-dose liposomal NAD+ aims to maximize utilization for restoring optimal function. May improve energy, sleep, mood, mitochondrial health, and DNA protection.

Sourced from non-GMO, soy-free ingredients. Made in the USA. Safe for daily use as a powerful anti-aging formula based on NAD+’s proven cellular rejuvenation properties.

NAD+ is critical for cells but decreases with time. Orgabay’s liposomal delivery claims near 100% absorption for substantial elevations from this high 500mg dose. Those seeking an absorbable, high-potency NAD+ supplement may find value in this liposomal formula.

3. Liposomal NAD+ Supplement

Maripolio Liposomal NAD+ provides a high-potency liposomal NAD+ formula to counter age-related decline. Each serving delivers 1000mg NAD+ enveloped in phospholipids for enhanced absorption. As a vital coenzyme, NAD+ supports energy production, cellular function, and brain health but decreases with age.

Liposomal NAD Supplement
Liposomal NAD+ Supplement

The liposomal delivery aims to maximize NAD+ utilization for anti-aging benefits. Made in the USA without GMOs, gluten, or additives.

As we age, NAD+ depletion can lead to fatigue, dysfunction, and cognitive decline. Maripolio uses a leading-dose liposomal NAD+ to effectively elevate levels. Those seeking an absorbable NAD+ supplement may find value in this high-potency formula.

Satisfaction guaranteed. Take 2 daily softgels to boost NAD+, cellular health, vitality, and brain function. Maripolio claims the highest NAD+ potency and absorption for anti-aging support.

4. HPN Supplements NAD3 NAD+ Booster

HPN Supplements NAD3 offers an advanced NAD+ booster to counteract age-related decline and support cellular health. As a vital coenzyme, NAD+ fuels key biological processes but decreases as we age. NAD3 aims to boost NAD+ levels for mitochondrial function, sirtuin activation, telomerase activity, and inflammation regulation.

HPN Supplements NAD3 NAD Booster
HPN Supplements NAD3 NAD+ Booster

According to HPN, NAD3 builds upon nicotinamide riboside research as the next evolution of their original anti-aging formula. It has undergone clinical testing to be an effective NAD+ elevator targeting cellular rejuvenation and longevity pathways.

Produced in the USA under NSF cGMP certification with independent BSCG purity testing. Non-GMO and gluten-free.

For those seeking an effective NAD+ boosting supplement, NAD3 claims superiority over nicotinamide riboside, offering the next generation of their research-backed cellular health formula. May benefit healthy aging, cognition, vitality, and disease prevention.

5. Double Wood NAD Supplement

Double Wood offers a 500mg NAD booster supplement to support cellular health and healthy aging. NAD is an essential coenzyme involved in cell metabolism that declines with age. By boosting NAD levels, this supplement aims to promote longevity, cognitive function, and immune health.

Double Wood NAD Supplement
Double Wood NAD Supplement

Sourced as 95% pure NAD, each vegan capsule provides 500mg alongside rice flour and vegetable capsules. Non-GMO and gluten-free. Manufactured in the USA under third-party purity testing.

As we age, NAD+ depletion can lead to cellular dysfunction. Double Wood provides an easy way to supplement NAD levels through a high-potency 500mg vegan capsule. Those seeking to counteract the effects of NAD+ decline may find value in this purified supplement for anti-aging benefits and overall wellness.

6. Life Extension NAD+

Life Extension NAD+ combines nicotinamide riboside as Niagen with enhanced bioavailable resveratrol and antioxidants. Niagen aims to boost NAD+ to support cellular energy and cognition. It’s paired with Life Extension’s specialized bio-optimized trans-resveratrol for increased absorption versus ordinary resveratrol.

Life Extension NAD
Life Extension NAD+

Additional antioxidants quercetin and fisetin augment resveratrol’s benefits for heart health, cellular function and inflammation response. Sourced from quality ingredients with purity testing. Non-GMO, gluten-free.

By efficiently elevating NAD+ while providing absorpable resveratrol and antioxidants, Life Extension NAD+ supports cellular vitality and healthy aging. Those seeking an NAD+ boost with scientifically-studied resveratrol may find value.


TRU NIAGEN is a patented NAD+ booster that uses Niagen, a proprietary form of nicotinamide riboside (NR), to support cellular health and healthy aging. By efficiently elevating NAD+ levels, which decline naturally with age, Niagen aims to enhance cellular energy, repair, and resilience against stressors.


Backed by 40+ patents and 300+ studies, Niagen is a superior NAD+ precursor compared to nicotinamide or niacin. It can raise NAD+ levels approximately 40-50% within 8 weeks of daily use. TRU NIAGEN is made in the USA under stringent safety and potency testing.

Thousands of customers report improved general wellbeing with consistent use. Supported by extensive research and testing, TRU NIAGEN offers a patented NAD+ boosting formula that may help maintain robust health amidst aging. Those seeking to counteract NAD+ depletion may find value in this researched Niagen supplement.

What is a NAD+ Supplement?

A NAD+ supplement is a form of dietary supplement that aims to increase the levels of nicotinamide adenine dinucleotide (NAD+) in the body. NAD+ is a crucial coenzyme that plays a vital role in various metabolic processes, including energy production, DNA repair, and cell signaling. It’s involved in redox reactions, carrying electrons from one reaction to another and thus driving the production of ATP, the energy currency of the cell.

As you age, NAD+ levels naturally decline, leading to metabolic and mitochondrial dysfunction. NAD+ supplements typically contain precursors to NAD+, such as nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN), which the body can convert into NAD+ to support and enhance these fundamental cellular processes.

Where do NAD+ Supplements Come From?

NAD+ supplements are derived from several precursors that are key to the biosynthesis of NAD+ in the body. The most common precursors used in these supplements are Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN). NR is often found in trace amounts in milk and other foods, while NMN is present in various food sources, including vegetables, fruits, and meats. However, the quantities in food are generally not enough to significantly impact NAD+ levels, hence the need for concentrated supplements.

Advanced biotechnological methods are employed to synthesize these compounds, ensuring purity and bioavailability. By providing these precursors, NAD+ supplements help to bypass the rate-limiting steps in NAD+ biosynthesis, effectively boosting its levels in the body.

How do NAD+ Supplements Work?

NAD+ supplements work by supplying the body with the necessary precursors that directly participate in the synthesis of NAD+. Once ingested, these precursors are absorbed and converted into NAD+ through various biochemical pathways.

This increase in NAD+ availability can have a profound effect on the body. It enhances energy metabolism by facilitating the conversion of nutrients into ATP, supports DNA repair mechanisms, and plays a role in the activation of sirtuins, a group of proteins involved in regulating cellular health and longevity. The increase in NAD+ levels can thus rejuvenate cells from the inside out, promoting health and potentially delaying the aging process.

Is NAD+ and Vitamin B the Same?

No, NAD+ and Vitamin B are not the same, but they are closely related. NAD+ is synthesized from Vitamin B3 variants, namely niacin, nicotinamide, and particularly nicotinamide riboside, a newly discovered variant.

While Vitamin B3 is an essential nutrient involved in numerous metabolic reactions, NAD+ acts as a coenzyme in redox reactions crucial for cellular energy production and other metabolic functions. The relationship between NAD+ and Vitamin B3 is a classic example of how vitamins can serve as precursors for complex molecules that drive vital biochemical processes.

What are the Benefits you can Get for NAD+ Supplements?

The benefits of NAD+ supplementation are wide-ranging and impactful. Primarily, NAD+ supports metabolic functions, including enhancing mitochondrial function and energy production. This can lead to increased vitality and stamina. Also, NAD+ plays a critical role in DNA repair and cell signaling, which can contribute to improved cellular health and longevity.

  • Enhanced mitochondrial function
  • Improved energy
  • Increased vitality and stamina
  • Improved cellular health and longevity

There is also evidence that NAD+ can improve cognitive function, protect against neurodegenerative diseases, enhance muscle health and function, and even act as a supplement for weight loss. It’s also been noted for its potential in skin rejuvenation and overall anti-aging effects. As research continues, the list of benefits associated with NAD+ supplementation continues to grow, highlighting its potential as a cornerstone supplement for health and longevity.

When is the Time should you Take NAD+ Supplements?

The optimal time to take NAD+ supplements can vary depending on individual routines and goals. Some people prefer taking them in the morning to kickstart their day with increased energy, while others might find them more beneficial at night as they aid in repair processes during sleep. The key is consistency and aligning the supplementation with your body’s natural rhythms. For personalized advice, consulting with a healthcare professional who understands your health profile and needs is always best.

What are the Potential Risks of NAD+ Supplements?

While NAD+ supplements offer numerous benefits, they are not without potential risks. Over-supplementation could potentially disrupt the body’s natural metabolic processes and lead to imbalances. Some individuals might experience mild side effects such as nausea, fatigue, headaches, or stomach discomfort.

  • Nausea
  • Fatigue
  • Headaches
  • Stomach Discomfort

There’s also the consideration of purity and quality of the supplements, as not all products are created equal. It’s crucial to choose high-quality supplements and consult with a healthcare provider, especially for those with underlying health conditions or those taking other medications.

Who should Take NAD+ Supplements?

NAD+ supplements can be beneficial for a wide range of individuals, particularly those interested in anti-aging, improved metabolic health, and increased vitality. They are particularly popular among older adults, athletes, and those with conditions associated with metabolic dysfunction. However, NAD+ supplements may not be suitable for everyone. Individuals with certain health conditions, those who are pregnant or breastfeeding, and children should approach NAD+ supplementation with caution and always seek medical advice before starting.

Can NAD+ Improve Digestion?

While direct evidence linking NAD+ supplementation to improved digestion is limited, its role in overall metabolism and cellular health might indirectly support digestive processes. NAD+ is crucial for the production of energy, which is necessary for the optimal functioning of all body systems, including the digestive system. However, more research is needed to understand the specific effects of NAD+ on digestion and gut health.

Can NAD+ Cause Liver Damage?

No, there is no significant evidence to suggest that NAD+ supplementation causes liver damage when taken at recommended dosages. However, as with any supplement, there is a potential for harm if taken in excessive amounts or if individuals have pre-existing liver conditions. Monitoring liver function and consulting with a healthcare professional before starting any new supplement, including NAD+, is advisable to ensure it won’t adversely affect liver health. Those with known liver issues should be particularly cautious and should always discuss their supplementation plans with a healthcare provider to avoid any potential complications.

Does NAD+ have Side-Effects?

While NAD+ supplements are generally well-tolerated, they can have side effects, especially when taken in high doses or without proper guidance. The most common side effects include nausea, fatigue, headaches, and gastrointestinal discomfort. These effects are typically mild and can often be mitigated by adjusting the dosage or taking the supplement with food. It’s crucial to listen to your body and consult with a healthcare professional if you experience any adverse effects, as this could indicate an underlying issue or a need to adjust your supplementation regimen.

What is the difference between Nicotinamide Adenine Dinucleotide (NAD) and Nicotinamide Riboside?

Nicotinamide Adenine Dinucleotide (NAD) is a coenzyme present in all living cells that’s essential for energy metabolism and cellular processes. Nicotinamide Riboside (NR), on the other hand, is a precursor to NAD+. This means that NR is converted into NAD+ within the body. The advantage of using NR supplements is that they can effectively increase the levels of NAD+ in the body, harnessing its benefits more directly. NR is often favored for its bioavailability and efficient conversion into NAD+, making it a popular choice in NAD+ supplementation for those looking to boost their levels of this crucial coenzyme.

What is the difference between NAD and NAC Supplements?

Nicotinamide Adenine Dinucleotide (NAD) is a crucial coenzyme involved in cellular energy production and metabolism. As a key player in the transfer of electrons in redox reactions, NAD influences numerous metabolic pathways and is essential for maintaining cellular health. Its levels naturally decline with age, which has led to interest in NAD supplementation as a potential means to combat aging and age-related diseases, as well as improve overall metabolic functions.

On the other hand, NAC Supplements are a derivative of the amino acid cysteine and acts as a powerful antioxidant. It’s known for its ability to replenish glutathione, the body’s primary antioxidant, and for its use in treating acetaminophen overdose and chronic respiratory conditions by breaking down mucus. NAC’s role in reducing oxidative stress and enhancing detoxification processes makes it a valuable supplement for a range of health issues, particularly those related to oxidative damage and inflammation.


In summary, NAD+ supplements offer a promising avenue for enhancing cellular health, supporting metabolic function, and potentially slowing the aging process. Understanding what NAD+ is, how it works, and the benefits and risks associated with its supplementation is crucial for anyone considering adding these supplements to their health regimen. While they offer numerous potential health benefits, they must be taken with consideration for individual health needs and potential side effects.

As research continues to unfold, NAD+ supplements stand at the forefront of scientific exploration into health and longevity, offering exciting possibilities for the future of wellness and preventive healthcare.

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Athletic Insight Research


The Athletic Insight Research team consists of a dedicated team of researchers, Doctors, Registered Dieticians, nationally certified nutritionists and personal trainers. Our team members hold prestigious accolades within their discipline(s) of expertise, as well as nationally recognized certifications. These include; National Academy of Sports Medicine Certified Personal Trainer (NASM-CPT), American College of Sports Medicine (ACSM), National Strength and Conditioning Association (NSCA-CPT), National Academy of Sports Medicine Certified Nutrition Coach (NASM-CNC), International Sports Sciences Association Nutritionist Certification.